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Ellero, J

And evidence suggests stopping the drugs seems to reverse many of those health benefits as well

If your autoimmune condition produces a metaphorical "volume 10" of inflammatory signaling, and tirzepatide turns that down to "volume 8" through metabolic improvement and modest immunomodulation, you still need your disease-specific medications to address the remaining signal

10.1172/JCI15595 90

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The gastrointestinal system contains a high concentration of GLP-1 receptors, which explains why digestive side effects are among the most commonly reported adverse reactions to semaglutide therapy