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Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)

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Discuss the approach with your healthcare provider based on your tolerance history

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A major clinical trial called the SELECT trial, published in the New England Journal of Medicine, followed over 17,000 people who were overweight or obese and had existing heart disease

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