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Both medications can affect heart rate, bupropion through norepinephrine stimulation and tirzepatide through the cardiovascular effects of GLP-1 agonism

doi: 10.1016/j.physbeh.2019.04.008

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Formally, these drugs are known as glucagon-like peptide-1 receptor agonists (GLP-1RA) and include Mounjaro and Zepbound

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These results represent a clinically relevant discovery, pointing to diminishing efficacy of exenatide in patients who develop high titers of emergent-treatment antibodies