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More recently, a cardiovascular outcomes trial further confirmed the cardiovascular safety of oral semaglutide in people with type 2 diabetes

If you lose weight too quickly without enough protein, you may lose muscle instead of fat, which can permanently lower your metabolic rate

Footnotes European Medicines Agency, Wegovy (semaglutide) EPAR Product Information, sections 4.2, 4.4 and 4.8

In contrast, GLP-1 signaling delays gastric emptying and the resulting GI discomfort may contribute to GLP-1s capacity to stimulate nausea and conditioned aversion

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A subsequent trial in obese patients with either non-insulin treated T2D or without T2D found an additional mean weight loss of 3.7 kg versus placebo [78]