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After treatment for 12 months, MDS-UPDRS Part III scores improved slightly by 0.04 points in the lixisenatide group and decreased by 3.04 points in the placebo group

blood pressure remains controlled Medication Tolerability: Occasional early satiety reported, but no severe adverse events One-Year Visit Weight: Down 9 kg overall (BMI 31 kg/m), approaching his target of losing 1012 kg HbA1c: 6.9%, well within the personalized target range set by his endocrinologist Lifestyle: Continues brisk walking 34 times weekly and has enrolled in a weight management support group Quality of Life: Richard reports feeling more energetic, with fewer episodes of low blood sugar after the sulfonylurea dose adjustment Discussion and Alignment with Research Findings Long-Term Projection: Based on modeling data akin to the CORE diabetes model, semaglutide may offer substantial long-term benefits, including lower risks of cardiovascular complications and improved survival (17)(18)

the lung findings were based on secondary or additional analysis

Side effect profile Both formats produce similar GLP-1-related side effects because they deliver the same active molecule

Nutrients 2022;14:209

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