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Patients with established cardiovascular disease Those with previous myocardial infarction, stroke, or peripheral arterial disease may benefit from the cardioprotective effects of certain GLP-1 receptor agonists, which include modest blood pressure reductions alongside other cardiovascular benefits

In elderly patients with stage 3 CKD, there was no effect of MRA on CV outcomes, potentially because two-thirds of patients stopped spironolactone treatment within 6 months predominantly because they met safety stopping rules (21)

Your dose may increase over weeks and months

Look for non-scale victories like better sleep, more energy, or clothes fitting differently

By framing the treat as a tool for social bonding, you bypass the veto

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