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J., Rheumatoid Arthritis: Past, Present and Future Approaches to Treating the Disease, International Journal of Rheumatic Diseases 20, no

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It has a very short half-life, approximately 12 minutes, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4)

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147 Leptin binds to the leptin receptor (LepRb) and activates JAK2/STAT3 pathway to decrease body weight and normalizes blood glucose concentration, meanwhile, JAK2 stimulates the phosphorylation of insulin receptor substrate (IRS1/2), then activates PI3K/Akt pathway and directly affect insulin action

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