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GLP-1 plays a critical role in insulin regulation, appetite control, and digestion, helping individuals feel satiated for extended periods after eating

Taking two doses close together concentrates the GI-slowing effects and dramatically increases the risk of nausea, vomiting, and other side effects

1 The two dominant incretins are glucagon-like peptide-1 (GLP-1), secreted by enteroendocrine L cells (located in the ileum and colon), and glucose-dependent insulinotropic peptide (GIP), secreted by K cells (located mainly in the duodenum)

This is particularly relevant for individuals using cagrilintide alongside insulin or sulfonylureas

However, their utility in other conditions, such as schizophrenia, cocaine addiction, and dementia, remains unsupported by robust evidence

Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as add-on to Metformin in patients with type 2 diabetes in SUSTAIN china: A 30-week, double-blind, phase 3a, randomized trial