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Whether the low endogenous concentration and the restricted pharmacokinetic action profile of endogenous GLP-1 metabolites are sufficient to elicit such effects under physiological circumstances remains questionable

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T., Schweitzer, M., Magnuson, T

Moreover, our results revealed similarities and differences in neural pathways, which possibly regulated different metabolic effects of GLP-1RA and SGLT-2i via sympathetic and parasympathetic systems in the CNS, such as feeding, blood glucose regulation and cardiovascular activities (arterial blood pressure and heart rate control)

Carmina, E., and R

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