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reported that in hippocampal slices in seizure-induced SpragueDawley rats, exendin939, a GLP-1 receptor antagonist, significantly decreased GABA A Rbeta2/3 expression and increased GluR expression (ie, GluA14, GluN1, GluN2A, GluN2B).Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 When samples were treated with GLP-1 RA, there was increased GABA A R2/3 expression and decreased GluR expression.Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 Overall, the included studies support that GLP-1 RAs may be associated with increased glutamatergic receptor activity via multiple cellular and molecular mechanisms (Figure 2)

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FDA data confirm that the most frequently cited GMP violations in inspections and warning letters consistently involve core quality system elements such as responsibilities of the quality control unit, production and process controls, laboratory controls, and production record review

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Contribution statement Both authors wrote and edited the manuscript and approved the final version