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With regard to RECOVER, this is apparently because trials funded by NIH must use doses that have an established toxicology and pharmacokinetic profile already accepted by FDA

doi: 10.1212/WNL.56.3.375 22

Kidney effects of Glucagon-Like Peptide 1 (GLP1): from molecular foundations to a pharmacophysiological perspective DOI: 10.1590/2175-8239-JBN-2024-0101pt Graphical Abstract Click to view Abstract GLP1 receptor agonists (GLP1-RAs) are drugs that mimic the effects of the incretin hormone GLP1 and were initially introduced in medicine for the treatment of diabetes in 2005 and for obesity in 2014

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When combined with GLP-1 activation, GIP agonism appears to improve tolerability while enhancing weight loss outcomes

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