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Semaglutide can be safely used in this patient population with modest weight loss and improvement in diabetic parameters

Chen H, Lei X, Yang Z, Xu Y, Liu D, Wang C, et al

In a recent study published in the journal Annals of Internal Medicine , a team of researchers from the National Institutes of Health's National Institute on Drug Abuse and the Case Western Reserve University School of Medicine investigated whether the glucagon-like peptide receptor agonist (GLP-1RA) semaglutide, which has been used to treat obesity and type 2 diabetes mellitus could improve health care measures related to tobacco use disorders

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Studies in genetically engineered animals may thus underestimate the number of GLP-1R populations in the brain involved in feeding, because, for illustration, it is intrinsically difficult to show whether a sub-population of brain GLP-1Rs mediates 10 or 20% of an effect