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The trial escalation tables stepped the amount up on a monthly cadence, beginning in the low single-digit milligram range and only advancing once the prior level felt comfortable

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Many people gain the weight back She said that more important than inducing weight loss, the medications can lower the risk of health issues associated with obesity, including diabetes, heart disease, stroke and some types of cancer

The treatment, called Tesomet, is a combination of two drugs: tesofensine, which affects certain brain chemicals, and metoprolol, which is a type of medication that targets the heart