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The FDA prescribing information for semaglutide and tirzepatide also carries a thyroid C-cell tumor warning from animal studies - the human relevance hasn't been established, but it's why patients with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome aren't candidates

3 Individual characteristics including age, sex, body mass index (BMI), and race have previously been implicated in the observed response to weight reduction intervention

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Combined with nutrition guidance and regular check-ins, this personalized approach ensures safe, gradual fat loss while improving energy, metabolism, and overall wellness

Food and Drug Administration also says in its safety profiles of these drugs that they should not be taken during pregnancy, noting there is "insufficient data" available
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