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1 Thus, their clinical use is expected to grow rapidly not only because of the obesity epidemic but as evidence expands to other indications such as cardiorenal disorders, metabolic liver disease, obstructive sleep apnea, peripheral vascular disease, depression, addiction, and neurodegenerative diseases

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As Epictetus might say, its not the drug that matters, but how we use it

However, these molecular mechanisms need to be further elucidated ( 2 The AMPK pathway AMPK is a serine/threonine kinase comprised of a catalytic alpha subunit and two subunits of beta and gamma regulators ( 3 The relationship between AMPK and antidiabetic drugs Metformin, the most widely used oral agent for the treatment of T2D, is historically known as an AMPK activator ( 3.1 SGLT2i and AMPK The SGLT2i (Sodium-glucose co-transport 2 inhibitors) are a class of antidiabetic agents, targeting the major glucose transporter SGLT2 in the kidney
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