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It is possible that the placebo effect may be enhanced in our study due to the shared decision-making process, whereby patients receive lifestyle advice and increased attention from their treating clinician, which may result in favourable behavioural changes [48]

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Any positive impact would have to be weighed against potential risks of using these medications, such as the risk of muscle loss, as muscle loss can lead to osteoporosis, a condition often associated with autoimmune diseases, she noted

About 4% of drug overdose deaths between 2019 and 2020 involved diphenhydramine and opioids like fentanyl, according to the CDCs weekly morbidity and mortality report of October 2022

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