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This narrow temperature range protects the peptide structure from heat-induced breakdown, which can reduce the medication's weight-loss efficacy by up to 30 percent if exposed to warmer conditions

Ozempic also carries the risk of more serious health concerns , including: Patients should be educated about the signs of serious side effects, like severe abdominal pain, persistent vomiting, or symptoms of low blood sugar

In trials Motus reported about 10.4 percent average weight loss over six months in human clinical trials, with much of the loss coming from fat rather than lean mass

Other gastrointestinal conditions would be evaluated on a case-by-case basis per trial protocol

[DOI] [PubMed] [Google Scholar] 969.Boels AM, Hart HE, Rutten GE

There is no FDA-established time limit for tirzepatide use