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Lancet 389, 13991409

Understanding the Risks and Making Informed Choices What We Know for Sure Research clearly shows: GLP-1 medications should not be used during pregnancy A 2-month washout period is necessary before conceiving Accidental early exposure doesnt automatically mean harm Animal studies show potential risks to developing babies Human data is limited but somewhat reassuring What We Dont Know Yet We still need more research on: Long-term effects on babies exposed during pregnancy Whether different GLP-1 drugs have different risk levels Impact on babies when used in the second and third trimesters Effects on breastfeeding and breast milk Making Your Decision Talk openly with your healthcare team about: Your weight loss goals Your pregnancy timeline Your overall health needs Your risk factors Your emotional readiness Together, you can create a plan that protects your health and your future baby

Note: Tirzepatide is technically a dual agonist (GLP-1 + GIP), meaning it targets two hormone receptors for potentially stronger effects

The first pathway reduces fat absorption (orlistat)

By chewing food thoroughly and taking more time during meals, we allow the stomach to register the quantity and taste of the food, helping us feel full faster and eat the appropriate amount

Meanwhile, this article focuses on evaluating the evidence of the current effects of GLP-1RAs on patients body composition, muscle mass and function in clinical trials, deeply explores the dual effects and heterogeneity of its efficacy, and analyzes the translational dilemma existing between preclinical positive discoveries and clinical outcomes.Furthermore, for the elderly population, this article further discusses the tolerance and nutritional risks faced during the treatment of GLP-1RAs