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Additionally, GIP directly stimulates lipogenesis, while GLP-1 indirectly promotes lipolysis, collectively maintaining healthy adipocytes, reducing ectopic fat distribution, and increasing the production and secretion of adiponectin from adipocytes

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For people who are sensitive to GI side effects, slower titration generally produces better tolerability

The Academy of Nutrition and Dietetics recommends eating slowly allows time for nutrient sensing in your gut to trigger hormonal cascades

10.1073/pnas.1218051109

Research published in the journal Climacteric demonstrates that while weight gain itself cannot be attributed solely to menopause, the hormonal changes substantially alter where fat accumulates