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however, heart failure with reduced ejection fraction also has a regional cause

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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

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These shifts carry strategic implications for operators and brands adapting product assortments, pricing and promotion strategies in foodservice channels