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Zhang ZJ, Yao ZJ, Liu W, Fang Q, Reynolds GP

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ID reports a grant from Astra Zeneca that is outside the scope of the submitted work

[5] [9] Zepbound was subsequently approved in November 2023 for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, dyslipidemia, or obstructive sleep apnea

The FDA issued a Drug Safety Communication in 2024 stating that their review did not find clear evidence of an increased risk of suicidal thoughts or actions with GLP-1 receptor agonists, though they continue to evaluate this safety concern