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Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation

We dont yet know the long-term consequences of sustained GLP-1 receptor activation in the brain. So far, tolerance has not clearly emerged

Additionally, chronic treatment with GLP-1 RAs increases the abundance of anti-inflammatory microbial taxa (e.g., Bacteroidetes), which has been associated with improvements in both mood and glycemic control [94,95,99]

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Dahl K, Toubro S, Dey S, et al

People arent just big mice who need a little bit of like a little screwdriver in their peptide