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J.et al (2022)
Similar therapeutic effects have been observed with OL-NP encapsulating exenatide, underscoring the potential of nanocarriers to achieve targeted delivery across the BBB and facilitate localized immune modulation [402404]
TM2, in particular, adopts a conformation in the orforglipron-bound structure that would be difficult to predict computationally, highlighting the receptor's conformational flexibility and the inherent limitations of structure-based drug design for class B GPCRs
The global rise in obesity, particularly in low- and middle-income countries, poses serious health challenges
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doi: 10.1007/BF01862957
