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The combination may result in additive or synergistic gastrointestinal distress, potentially severe enough to cause dehydration, electrolyte disturbances, or medication non-adherence

Yes, tirzepatide is more effective than semaglutide for promoting blood sugar control in type 2 diabetes and reducing body weight due to its dual action at GLP-1 and GIP receptors

JCI Insight

Side effects, when they occur, are usually mild gastrointestinal symptoms that ease over time

Support for fat loss: Mounjaro helps the body preferentially lose fat mass, helping to preserve muscle during weight loss

In a clinical trial involving over 3,900 patients across 40 countries, liraglutide demonstrated improved glycemic control as monotherapy by reducing HbA1c values compared with placebo or active comparators