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Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal

After 82 wk of treatment of T2DM patients with exenatide, the placebo-subtracted weight loss from baseline is approximately 5% [886]

[DOI] [PMC free article] [PubMed] [Google Scholar] 237.Eberly LA, Yang L, Essien UR, et al

This indicates that the AD mice treated with the GLP-1RA displayed memory function comparable to the genetically modified mice with regular memory function, both showing significant improvements over the vehicle-dosed AD SAMP8 mice (Figure 4B) [57]

Others think it changes the way the body stores and uses fat

Semaglutide: Ozempic, Wegovy, and the GLP-1 Revolution Semaglutide marketed as Ozempic for type 2 diabetes management and Wegovy for chronic weight management is a once-weekly injectable GLP-1 receptor agonist that has transformed the landscape of obesity medicine