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Targeting the incretin system in obesity and type 2 diabetes mellitus

by Dennis Crouch Since late 2022, the extraordinary demand for glucagon-like peptide-1 receptor agonists (GLP-1s) like Eli Lilly's tirzepatide (marketed as Mounjaro for diabetes and Zepbound for weight loss) has created a persistent nationwide shortage

Tirzepatide is a new drug that has shown promising results in clinical trials for weight loss

Ideal for patients continuing therapy on a shorter refill schedule who want needle free weight loss

Try short daily practices you can sustain, such as: A 20-minute walk Focused breathing for five minutes A brief guided meditation before sleep Social connection and a consistent sleep schedule reduce physiologic stress, too

Plan your meals in advance and designate specific eating times rather than grazing throughout the day