ada standards of care 2025 glp-1 dpp-4 combination not recommended in Diabetes Frontiers | A decade of

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Post hoc pairwise comparisons were performed for significant interaction effects using estimated marginal means with Sidak correction to control for multiple comparisons

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Early studies of GLP-1s suggested higher percentages, around 40%, which raised concern

Robust evidence from multiple landmark trials demonstrates their consistent ability to reduce major adverse cardiovascular events by 14%, with notable benefits extending beyond glycemic control