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Clinical trials have primarily focused on Mounjaros effectiveness in use alone or with other diabetes medications, but not with additional GLP-1 drugs

(2019), GT and AST levels were drastically reduced, with little to no change in AST levels

Compounded GLP-1 medications are not FDA-approved as finished products

Gallbladder issues Gallbladder issues and gallstones are a recognized risk with GLP-1 medications, particularly with significant rapid weight loss

However, clinicians should remain vigilant for signs of excessive metabolic suppression or thyroid dysfunction, particularly in patients with pre-existing thyroid conditions or those experiencing symptoms beyond cold intolerance, such as severe fatigue, hair loss, or cognitive changes that might suggest thyroid hormone imbalance requiring investigation

[2] [4] These injectable medicines mimic the action of naturally occurring GLP-1, a hormone produced in the intestine following food intake