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The most common AEs recorded following administration of PF-06882961 were nausea, vomiting, and decreased appetite, all of which were considered treatment-related by the investigator and consistent with the expected effects of the GLP-1R agonist mechanism

Common gastrointestinal side effects reported with the 17.2 mg dose included nausea (35%), diarrhea (25%), constipation (24%), vomiting (24%), abdominal pain (14%), and dyspepsia (13%)

The cell biology of bone metabolism

Seventy-four participants in each cohort were excluded for having a pre-existing diagnosis of heart failure

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J Cardiovasc Transl Res 17(1):121132 Mahmod M, Pal N, Rayner J, Holloway C, Raman B, Dass S, Levelt E, Ariga R, Ferreira V, Banerjee R et al (2018) The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: a cardiovascular magnetic resonance study