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Both show GI side effects nausea, diarrhea, constipation that are predominantly mild to moderate and improve over time as the body adapts

But resection experiments clearly indicated the presence of an additional incretin, and in 1986, an unexpected processing fragment of the recently identified glucagon precursor, proglucagon, namely truncated glucagon-like peptide 1 (GLP-1 736 amide), was isolated from the gut and found to both stimulate insulin secretion and inhibit glucagon secretion

Although you will start at 1.5 mg once a day, the starter dosage mentioned above, in practice most patients will have to escalate or titrate their dosage every 30 days until they get to the standard dose of 25 mg daily