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"It would be nice to optimize the brain's reward pathway to help our patients out though, and not have them suffer through the cravings." Anhedonia might be a dosing problem, not a drug problem Reports of anhedonia and emotional blunting on GLP-1 agonists have generated real concern

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2012;125:11571170.

Here are some other conditions that have been associated with Mounjaro: Gallbladder disease (cholelithiasis/cholecystitis): reported with GLP-1/GIP therapyseek care for persistent RUQ pain/fever/jaundice Acute kidney injury: often secondary to dehydration from GI effectsmonitor renal function if symptoms are significant Hypoglycemia: risk increases when used with insulin or secretagogues

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Finally, evaluate combinations with dietary interventions and orthogonal metabolic agents to delineate additivity versus redundancy within energy-balance networks