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Clinicians should evaluate individual risk factors, comorbidities, and contraindications when choosing patients for treatment, balancing possible benefits with associated dangers

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It does not activate GIPR

Tirzepatide activates both GLP-1 and GIP receptors, targeting two separate appetite-regulating pathways

J., Stewart, R

Cytosolic and mitochondrial pools are functionally compartmentalized, and exchange between these domains occurs indirectly through metabolite shuttles [110]
