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Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

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Algumas formulaes, como o tirzepatide, combinam esses dois mecanismos, enquanto outras, como o retatrutide, adicionam uma ao sobre o glucagon, formando um agonista triplo.O GLP-1 um hormnio intestinal da famlia das incretinas, principalmente conhecido por estimular a secreo de insulina com base na glicose presente no sangue