glp 1 agonist action GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes Mechanisms of Action and Therapeutic

For context on what postpartum weight loss looks like more broadly, the postpartum weight loss and Ozempic article covers the full picture of when and how GLP-1 medications fit into the postpartum period

GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

Several indirect mechanisms may contribute to fatigue in patients taking GLP-1 receptor agonists

There is increasing recognition of the impact of obesity on workforce health (and as a result, on GDP), which further strengthens the case for healthcare systems investing more to enable additional widespread uptake of GLP-1RAs

Glucagon receptor activity is studied for possible effects on energy expenditure and lipid metabolism in certain models

Shaefer CF, Kushner P, Aguilar R