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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

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The GLP-1 NAION vision-loss MDL hit 146 cases on the July JPML report up 70% in two months as the GI-injury MDL heads to Rule 702 hearings September 10-18.