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Description
GLP-1 stimulation of adipose tissue monocytes increases IL-6 signaling in adipocytes, leading to increased UCP-1 expression and glucose metabolism [112]
Tirzepatide (GLP-1 + GIP) reaches approximately 22.5%

Finkelstein, professor, Duke-NUS Medical School, Singapore, in a commentary about the study

Who qualifies for semaglutide injections for weight loss

clinicians should consult trial protocols, seek endocrinology input, and document clinical rationale with informed consent

Women with PCOS taking Ozempic should use effective contraception
