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Diabetologia (2010) 53(1):1539

According to epidemiological data from different countries, lifetime incidence rate of AA can be as high as close to 20% (14), and the global incidence rate of AA has increased by more than 60% in the past 30 years (5)

Some users report brief initial consultations focused mainly on qualifying questions rather than comprehensive care planning

The skin may become thickened, with reduced elasticity and increased susceptibility to infection (cellulitis), which can trigger acute inflammatory episodes and further compromise lymphatic function