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Ultimately, a Cu(I)-catalyzed coupling-cyclization enabled the formation of the tricyclic structure of the potent DPP-4 inhibitor 44 (Figure 6) (116)

These therapies are increasingly recognized for their benefits in managing cardiovascular, renal, and metabolic conditions, which are common comorbidities among patients with T2D

The active pharmaceutical ingredients (semaglutide and tirzepatide) are based on FDA-approved compounds, but compounded formulations operate under the 503A regulatory pathway that allows pharmacies to customize medications for individual patients

Chiurazzi M, De Conno B, Di Lauro M, et al

To take Trulicity, users take the cap off of the pen, twist one end to unlock, and then place the flat end of the pen to their skin