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Among people who did not currently have a substance use disorder, Al-Aly studied their likelihood of becoming addicted to alcohol, cannabis, cocaine, nicotine, or opioids over a three year follow-up period after being prescribed either a GLP-1 or a SGLT2 inhibitor

Additionally, the trials have reported potential cardiovascular effects, such as dose-dependent increases in heart rate and a small number of cardiac arrhythmia cases
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[23] [24] Pharmacists can also provide valuable advice regarding potential interactions and the quality of berberine supplements

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