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Patients with active GI side effects: If nausea, vomiting, or diarrhea from dose escalation are ongoing, alcohol is likely to worsen both

Very common side effects (affecting more than 1 in 10 people): Nausea: This is the most frequently reported side effect, particularly during the initial weeks of treatment or following dose increases

This is associated with reduced noradrenaline content in the pancreas and blocked by an 2 -adrenergic receptor agonist, implicating functional involvement of the sympathetic nervous system (SNS)

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Especially regarding the central nervous system, the expression of GLP-1 receptors in reward-related regions, such as the hypothalamus, amygdala, nucleus accumbens, paraventricular nucleus, ventral tegmental area, locus coeruleus, and brain stem [21] may suggest a possible association between reward learning and symptoms like anhedonia in diseases such as depression