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However, these medications are available in combination with metformin or other antihyperglycemic agents, which may provide the advantage of decreased pill burden for patients with uncontrolled diabetes

2.41% of people taking DPP-4 inhibitors developed epilepsy

Sadek MA, Kandil EA, El Sayed NS, Sayed HM, Rabie MA

Diabetes Care 2012;35:252258

Medication storage and handling also differs between the two classes, and this affects long-term convenience

Notably, GIP is secreted by the enteroendocrine K-cells that are present in high density in the duodenum and upper jejunum, while GLP-1-producing cells of the intestine are mainly positioned in the distal parts of the gut [44]