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doi: 10.1007/s10571-017-0543-8
Hormonal Regulation of Appetite and Metabolism in Women
2024 [cited 2025 December 20]
In individuals with T2D, epigenetic modifications, specifically increased DNA methylation of the GLP-1R gene, reduce receptor expression, impairing the function of GLP-1 and lowering insulin secretion
Wegovy pill is used with a reduced-calorie diet and increased physical activity for adults with obesity or with overweight who also have weight-related medical problems, to help them lose weight and keep it off
As Daniel Drucker explained in the companion podcast, that isnt necessary to achieve the GLP-1 mediated suppression of inflammation in the brain
