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They are generally not recommended for patients with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), those who are pregnant or breastfeeding or planning pregnancy, patients with a known allergy to the medication, severe gastroparesis or serious digestive motility disorders, active pancreatitis or significant pancreatitis history, serious gallbladder disease, certain kidney conditions, or active eating disorder concerns

For someone already predisposed to migraines, this mechanical stress can initiate a full attack

I lost 5 kg in the first 12 weeks, and my blood pressure normalised

A formulation patent claiming a pharmaceutical composition comprising compound A and a pharmaceutically acceptable excipient may have survived examination only after the applicant argued against a prior art reference that disclosed a similar formulation