what is gip/glp-1 Why does GLP‐1 agonist combined with GIP and/or GCG agonist have greater weight loss effect than GLP‐1 agonist alone in obese adults without type 2 diabetes? - Jiang - 2025 GIP and GLP‐1, the two

Key Mechanism: Fiber slows digestion Reaches the colon fermented by gut bacteria Produces compounds that trigger GLP-1 release Two-Phase Effect: Immediate GLP-1 release after eating Second boost (48 hours later) Second Meal Effect Helps: Reduce cravings between meals Improve next-meal appetite control Best Fibers for GLP-1 Fermentable Fibers (Most Effective) Beta-glucans: Oats Barley Rye Seaweed Mushrooms Other Soluble Fibers Apples Pears Legumes: Lentils Chickpeas Peas 2

[USA] GLPs JDC Burst 1 has received the Parnelli Award for Indispensable Technology [...]

This specific prebiotic inhibits DPP-IV enzyme activity, extending the lifespan of GLP-1 for prolonged effects on glucose regulation and hunger suppression.*

But researchers arent done sharpening the edge

In a trial, people lost 75% fat and 25% muscle.

Weight loss with inflammatory bowel disease requires careful medication selection