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This triple-action mechanism distinguishes it from existing approved therapies such as semaglutide (GLP-1 receptor agonist only) or tirzepatide (GLP-1/GIP dual agonist)

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Part Fourteen: The Future of Patent Cliff Dynamics How Drug Price Negotiation Changes the Calculus The Inflation Reduction Act of 2022 introduced direct Medicare drug price negotiation for a defined set of high-expenditure drugs, beginning with small molecules that have been on the market for at least nine years and biologics that have been on the market for at least 13 years [42]