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India is home to over 100 million people with diabetes and approximately 250 million classified as obese or overweight.[15] What makes the situation uniquely dangerous is the Thin-Fat Indian paradox: South Asians tend to accumulate more visceral (belly) fat, liver fat, and less lean muscle mass at lower body weights than Western populations.[8][9][10] While GLP-1 medications are a global phenomenon, they are particularly critical for the Thin-Fat Indian phenotype

Researchers found that overweight adults without diabetes lost an average of 16% of body weight over the course of 68 weeks when they received a once-weekly subcutaneous 2.4 mg semaglutide injection

However, these agents can be expensive for patients whose insurances do not cover the medications

It is also reasonable to assume this risk is greater the deeper the depth of sedation when the patients protective reflexes that prevent aspiration are less intact
