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however, it exerts a dual pharmacological effect by concurrently targeting both the GLP-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR) [11]

Key Takeaways for Athletes Using Semaglutide Semaglutide is not a performance-enhancing drug It does not boost strength, endurance, or speed directly

Disproportionality analyses, including ROR and IC 025 , quantify reporting patterns relative to background rates and do not measure clinical risk or incidence.Reference Prieto-Merino, Quartey, Wang and Kim 45 Accordingly, an IC 025 value below zero indicates an absence of disproportionality rather than a signal of protection.Reference Prieto-Merino, Quartey, Wang and Kim 45 These metrics are meant to detect safety signals, not infer benefit

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Breath testing evaluates fermentation, absorption, and intestinal motility

Furthermore, whereas sex-specific effects of GLP-1 have been reported for its metabolic outcomes and reward behaviors (28,29,58), research revolving GLP-1s effects on cognition and neuroprotection have been conducted mainly in males