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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction

The launch of oral GLP-1s coupled with lower prices and broader access (including Medicare and Medicaid coverage in the U.S.) should drive higher utilization and market penetration as more affordable and convenient options become available. Chris Schott Senior Analyst covering the U.S