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Dose escalation can temporarily restart mild symptoms, but slow titration schedules minimize this rebound

Circadian rhythm and metabolic timing There is a growing body of research on how circadian rhythms affect drug metabolism and metabolic function

23,24 A post hoc analysis of the Look AHEAD trial reported that at least 10% weight loss in the first year was associated with a 21% lower risk of major adverse cardiac events

The trials were not designed to detect a difference in terms of these outcomes, and none of the analyses were controlled for multiplicity

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