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doi: 10.3389/fendo.2013.00076 6 SpitzCWinkelsHBrgerCWeberCLutgensEHanssonGKet al
Extensive impact of non-antibiotic drugs on human gut bacteria

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The first and fundamental therapeutic approach to curb the pandemic problem of obesity must be a change in the lifestyle through an adequate diet and the practice of a regular physical activity program adapted to individual abilities and state of health [28]

Due to the above-mentioned effects of TZD on glycemic, hepatic metabolism, and inflammation, treatment with dual-agonism may reduce or reverse liver damage (lobular inflammation, hepatic steatosis, liver cell damage, and fibrosis) and metabolic dysfunction ( GLP-1RA has multiple hepatic effects on MAFLD, involving an adaptation of portal and plasma glucagon and insulin concentrations, hepatic insulin sensitivity and improving hepatocyte mitochondrial function ( There is a randomized controlled phase 2 study with the objective to explore the use of TZP as a treatment for MAFLD, providing strong evidence [NCT04166773]